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Enclomiphene citrate is a novel oral drug that blocks estrogen receptors and stimulates gonadotropin secretion in men with secondary hypogonadism. This article reviews the clinical trials and pharmacological properties of enclomiphene citrate, and compares its efficacy and safety with clomiphene citrate, a widely used but off-label treatment for male infertility. Enclomiphene (Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene constitutes the trans-stereoisomer of clomiphene citrate, a drug that has been widely prescribed for several decades for the treatment of ...

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